Harry Brook top-scored for England with 91 runs, while Jordan Cox made 73, Joe Root scored 66 and Larsen contributed 51. England faced 89.5 overs in their first innings.
Pakistan’s left-arm spinner Ali Usman was the standout bowler, claiming five wickets for 95 runs. Khurram Shahzad took three wickets for 133 runs, while Mohammad Abbas and Mohammad Ali picked up one wicket each.
England had resumed play on the third day at 366 for eight, holding a 195-run lead after Pakistan were dismissed for 171 in their first innings.
For Pakistan, Abdullah Shafique was the leading scorer with 61 runs, followed by Imam-ul-Haq with 42 and captain Salman Ali Agha with 21.
Ali Usman also created history by becoming the first Pakistan left-arm spinner to take five wickets in a Test innings in England.